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The ratio of reduced glutathione (GSH) to its oxidized form (GSSG) dropped from 18.9 in young adults to 7.4 in elderly subjects

HMDB: a knowledgebase for the human metabolome

All species generate NADPH intracellularly, which fuels disulfide reductase systems Mammals have an NADPH-independent disulfide reductase system fueled by methionine Transsulfuation reversal allows Met-fueled reductase system yet makes Met essential Transsulfuration reversal and a Se- dependent TrxR family co-evolved with metazoans Metazoan selenoprotein TrxR1 and transsulfuration each support redox signaling Acknowledgments Funding to the authors came from the US National Institutes of Health (AG055022 and CA215784)

Cadmium exposure during puberty damages testicular development and spermatogenesis via ferroptosis caused by intracellular iron overload and oxidative stress in mice

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Artificial Intelligence Approaches to the Biochemistry of Oxidative Stress: Current State of the Art