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The cumulative release of the IM2 and NE1 peptides from a 1% poloxamer formulation was assessed over 420 h

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FOXO4-DRI vs nearby senolytics Option FOXO4-DRI Type D-retro-inverso peptide Human trial stage None (preclinical only) Option Dasatinib + Quercetin (D+Q) Type Small-molecule drug + flavonoid Human trial stage Early human trials (e.g., Alzheimer's) Option Navitoclax Type BCL-2 family inhibitor Human trial stage Later-stage trials (e.g., myelofibrosis) D+Q and navitoclax are further along in humans but can affect healthy cells (e.g., low platelets)

1999], the effector molecules phosphatidylinositol 3-kinase (PI3K), phospholipase C (PLC) and v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (SRC) [Ponzetto et al