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First, TLC-2716 caused dose-dependent reductions in the TG/HDL-C ratio and Lipo-IR index, both surrogate markers of insulin resistance, suggesting that TLC-2716 may improve insulin sensitivity, as observed in preclinical studies

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Here, we summarize the features, process, function, and mechanisms of ferroptosis, discuss its relevance with oxidative stress and cellular inflammation linking to cardiovascular disorders, raise the unsolved mysteries of ferroptosis, and provide new insights to consider the ferroptosis as the therapeutic target for the prevention and treatment of CVDs

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