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Paumen MB, Ishida Y, Han H, Muramatsu M, Eguchi Y, Tsujimoto Y et al

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doi:10.1056/NEJMoa1109400 69

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When the carotid artery and cerebral cortex of subjects within the control group were inspected, a high level of autophagy markers, light chain 3 (LC-3) and Beclin-1 (BECN-1), and apoptosis was found within the carotids as well as endothelial, vascular and cerebral cortex evidenced by a significant rise in caspase-3 expression and reduced Bcl-2 mRNA gene expression

L'effet demeure faible et non significatif pour des doses respectivement 2, 4 et 8 fois plus leves.The effect remains weak and not significant for doses 2, 4 and 8 times higher respectively
