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It is essential that hydroxocobalamin therapy is continued for life
Unlike native IGF-1, which requires frequent dosing, IGF-1 LR3 maintains more stable plasma levels throughout the day [11]
doi: 10.1038/s41419-022-05459-4
In the liver, the accumulation of lipids is thought to impair mitochondrial function, thus reducing fatty acid oxidation and increasing the production of reactive oxygen species (ROS) that trigger lipid peroxidation, DNA damage, and apoptosis
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The ligand-bound protein showed significant stability in the major part of the simulation
