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2 Currently, there is no curative treatment established for ALS, and since there are only limited number of medicines approved in Japan and abroad, this is a disease with significant unmet medical needs

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It induces cytokine production and stimulates angiogenesis

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Given that distinct microbial derivatives act through unique molecular targets and pathways to regulate the enteric nervous system (ENS), this review adopts a categorical approach to elucidate the mechanisms underlying their crosstalk more clearly within the gut microbiota-ENS axis ( Figure 3 )