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Metformin, the most widely prescribed treatment for type 2 diabetes mellitus (T2DM) and well-known geroproector, has been reported to delay or alleviate senescence phenotypes across multiple cell types and senescence causes

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Notably, stimulation of the HPA axis by AgRP neurons is independent of their induction of hunger, showing that these canonical hunger neurons drive many distinctly different adaptations to the fasted state

Flexibility and mobility: By promoting tissue remodeling and reducing adhesions, TB-500 can improve flexibility and reduce stiffness after injuries

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Clin Pharmacol Ther 2018