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And, clearly, there are shortcomings to the current drug-approval process

The medication triggers the death of the inflammation-driving B-cells via two main mechanisms: antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)

Moreover, besides GzmB, limited information has been revealed regarding the endogenous inhibitors of Sb9 or the pathways regulated by Sb9

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In people with myasthenia gravis, however, the muscle endplates have a compromised architecture that is significantly smoother and with much fewer acetylcholine receptors than their healthy counterparts

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