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Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype

Rather than starting at 500mcg, consider beginning at 200-250mcg for the first week

The British National Formulary (BNF), for example, differentiates the prescription of hydroxocobalamin according to presenting symptoms, eg, For neurological involvement, it is advised to administer hydroxocobalamin by intramuscular injection, initially 1 mg once daily on alternate days until no further improvement, then 1 mg every 2 months. In the Netherlands, pharmacotherapeutic guidelines 51 recommend (for the same neurological symptoms or abnormalities) administration of 1000 mcg once or twice weekly for up to two years

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The internal optimization creates a biological environment where aesthetic treatments produce better, more durable results