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cerevisiae Adh2p functions in glucose-depleted conditions, and converts ethanol to ACH in vitro [24]

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This reaction prevent toxic accumulation of tiglyl-CoA and also releases the CoA so that it can be utilized by other mitochondrial metabolic processes such as fatty acid -oxidation

The collective work of many labs has revealed complex roles of NHR-49 in the regulation of metabolism, lifespan, and stress responses
