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Moreover, melatonin has been shown to promote cardiomyocyte survival through the Apelin/SIRT3 signaling axis, inhibiting excessive mitophagy and preventing myocardial ischemia-reperfusion injury [111]

58 Long-term or extreme ERS also leads to endoplasmic reticulum dysfunction and further induces cell apoptosis

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doi: 10.1016/S0928-0987(98)00061-X

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