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The absence of approval means there is no licensed manufacturer, no quality standards enforced by health authorities, and no legal framework for medical use

The number of detectable NPs in the brain parenchyma increased over 22 h, indicating the crossing of the BBB

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B vitamins generally have a low risk of interacting with medications, though some medications can impair or enhance their absorption

doi: 10.1016/j.ejps.2020.105410