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In osteoarthritis, fisetin also suppressed IL-1-induced production of TNF-, IL-6, COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5 via activation of SIRT1 [69,70]
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doi: 10.1021/acs.est.5b01233
[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Ayloo S, Lazo CG, Sun S, Zhang W, Cui B, Gu C
