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The significance of timing in combination therapy was brought to light by a study conducted by Eastwood et al., which showed that in a model of electrode insertion trauma, sequential delivery of dexamethasone and NAC was more efficacious than simultaneous delivery [4]
casei on intestinal barrier dysfunction and the possible relationship with mast cells

Based on the available data, we hypothesize that the maintenance of metabolic homeostasis involves the support of ATP synthesis, the suspension of basic normoxic programs (anabolism/catabolism, etc.), the removal of critical consequences (glutamate metabolism, activation of autophagy, and ROS scavenging), the activation of stabilization/recovery programs due to existing cellular resources and expediency

Flanagan RJ, Braithwaite RA, Brown SS, Widdop B, deWolff FA (1995) Basic Analytical Toxicology
First, most studies are limited to correlative studies or short-term in vitro models, and there is little causal evidence linking disrupted organelle interactions to oocyte dysfunction and reduced fertility
