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In vivo , 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice exhibited a marked reduction in tyrosine hydroxylase (TH)-positive neurons and CD31 expression, along with significant decreases in GSH and GPX4 levels

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Additionally, a triple dosage may be considered in specific circumstances

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences

Yoto et al., 2012)

[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Li Y.D., Chi W.Y., Su J.H., Ferrall L., Hung C.F., Wu T.C