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The deposition of acylcarnitine also disrupts the function of the Na + -K + -ATP pump and affects the action potentials, polarization, hyperpolarization, and depolarization cycles of the myocardial cell membrane, which further affects the electrophysiological stability of the heart [295]

Serum indoxyl sulfate levels may be a predictive mechanistic biomarker of the severity of coronary artery disease because they have a positive correlation with coronary atherosclerosis scores (115)

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They accumulate and cause cellular damage