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Recent evidence suggests that in ovarian cancer, NNMT expression is associated positively with PGAM1, which is involved in the Warburg effect, enabling the elucidation of the resistance mechanism of bevacizumab

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Based on the shared pathogenesis, including estrogen regulation and inflammation, potential therapeutic drug targets (cholecystokinin B receptor and phosphodiesterase 4B) were identified, providing evidence of shared disease etiology and implicating clinical diagnostic and treatment decisions for both diseases (131)