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Succinyl-CoA allosterically inhibits HMGCS2 and it also serves as a substrate for succinylation of lysine residues in the enzyme

CashmanJRXiongYLinJVerhagenHvan PoppelGvan BladerenPJet al

Carnitine does not have an established tolerable upper intake level [1]

Glycogen synthesis/phosphorolysis is regulated via phosphorylation of cognate enzymes, absent a requirement for gene activation or de novo protein synthesis

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Here, we review the known pathogenic mechanisms of oxaliplatin- and paclitaxel-induced CIPN, highlighting recent findings