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A large 24-week trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo when combined with diet and exercise

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The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake

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It may absorb up to 12% of water if exposed to air