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Intranasal administration of the optimized formulation exhibited 5.5 times greater relative bioavailability than oral administration of the drug solution, which was attributed to the avoidance of the first-pass effect and enhanced drug permeation across the nasal mucosa

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88 Similarly, exosomes derived from UCMSCs suppress EMT progression by downregulating the TGF-/Smad axis

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Tesamorelin is structurally modified to remain active longer in the body

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