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Consequently, HMGB1 is not only involved in the regulation of melanocyte survival and function but also exacerbates vitiligo progression by activating inflammatory and autoimmune responses

Our previous study indicated that GSSSG attenuated LPS-induced activation of the NF-B signaling pathway through inhibition of p65 phosphorylation 33

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At 6 and 12 months, a phase II trial with 45 patients tested the treatment in a randomized, doubleblind study