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A study of 4,230 people (average age 19) with acne showed that applying cream containing 25% milk thistle fruit extract twice daily for 812 weeks reduced acne severity by 0.8 points (on a 05 scale) compared to baseline (Bageorgou, J Cosmet Dermatol, 2023) [43]

The rest of the authors declare that they have no relevant conflicts of interest

But these findings are still early: so far, the nasal spray has only been tested in laboratory mice