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Authors' contributions AW, YN and JS wrote and edited the manuscript

Inhibition may occur as a direct result of administering polypeptides, or antibodies directed to said polypeptides as described elsewhere herein, or indirectly, such as activating the expression of proteins known to inhibit metastasis, for example alpha 4 integrins, (See, e.g., Curr Top Microbiol Immunol 1998;231:125-41, which is hereby incorporated by reference)

Machine learning algorithms Support vector machines SVM is a machine learning technique that was originally designed to solve classification problems but has since been generalized for application to continuous models such as those needed to predict pKa values

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