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AOD-9604 originated from research at Monash University in the 1990s seeking to isolate the lipolytic domain of human growth hormone from its growth-promoting and metabolic-side-effect domains

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Its mechanism of action is based on binding LPS as well as IL-1 and TNF-, which are components of the cell wall of Gram-negative bacteria, leading to their release from the bacterial wall, destruction of the cell wall, resulting in the death and destruction of the microbial cell

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