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Increasing evidence also demonstrates that CSVD frequently coexists with neurodegenerative disorders such as Alzheimers disease, contributing substantially to mixed dementia syndromes

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Current models for studying microbial TMA production have numerous weaknesses including the cost and length of human studies, differences in TMA(O) metabolism in animal models and the risk of failing to replicate multi-enzyme/multi-strain pathways when using isolated bacterial strains

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