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Kirk JM, Trainer PJ, Majrowski WH, Murphy J, Savage MO, Besser GM

The GSK-3 inhibitors SB 216763, as well as two histamine H 3 receptor agonists, provided benefit in a mouse model of motor hyperactivity or stereotypies resulting from dopamine D 1 agonist exposure, Reference Miller, Tallarida and Unterwald38,Reference Rapanelli, Frick and Horn39 and the antidyskinetic benefit afforded by TDZD8 (GSK-3 inhibitor) administration in a rat model of levodopa-induced dyskinesia was blocked by pretreatment with a selective dopamine D 1 agonist

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View our lab testing program How do 5-Amino-1MQ and Methylene Blue's proposed mechanisms relate to NAD+ pathway and mitochondrial research

Notably, mitochondria maintain a distinct pool of GSH that is independent of cytosolic GCL activity