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The microbiome-gut-brain content axis consists of three bidirectional, biochemical, signaling pathways between the gut and the brain, and these three pathways include the nervous, endocrine, and immune pathways (198)

When your body lacks this vital nutrient, you may experience a range of debilitating symptoms, including persistent fatigue, anemia, neurological challenges, digestive disruptions, mood swings, muscle weakness, vision impairments, glossitis, and even skin pallor or jaundice

The reason we care is that citrulline is converted by the body into arginine which is one of many amino acids that the body DEFINITELY uses to make proteins

These findings indicate that this form of communication is essential for proper central nervous system development and function

In fibromyalgia, oxidative stress has also been linked to pathophysiology (Cordero et al., The importance of oxidative stress in chronic disease is further exemplified by Long COVID, a condition that has emerged following the COVID-19 pandemic and shares many clinical features with ME/CFS (Astin et al., The presence of fibrinolysis-resistant micro-clots in the vasculature of Long COVID patients, as described by Pretorius et al

This effect may be more noticeable in patients with lighter eye colors and may be permanent even after discontinuation