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10.1016/j.ijbiomac.2023.126038 17 ChenS.-K.WangX.GuoY.-Q.SongX

IGF-1 Upregulation Downstream Anabolic Signaling Both peptides indirectly stimulate insulin-like growth factor-1 (IGF-1) production through sustained growth hormone elevation: Growth hormone binds to hepatic GH receptors activating JAK-STAT signaling pathways Increased transcription of IGF-1 gene in liver tissue Elevated plasma IGF-1 levels mediate anabolic effects in muscle, bone, and adipose tissue IGF-1 provides negative feedback regulation preventing excessive growth hormone secretion Studies report IGF-1 increases of 1.5- to 3-fold for 9-11 days following CJC-1295 administration, with the ipamorelin combination providing more sustained elevation

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Figure 2 The Effect of GSTP on HMGB1 Release Is Independent of Its Transferase Activity As GSTP is an enzyme involved in phase II metabolism (1), we next analyzed if the inhibitory effect of GSTP on HMGB1 release was related with its catalytic activity

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