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This can cause damage to cells and tissues, leading to chronic inflammation. The activation of the Nrf2 pathway by sulforaphane reduces oxidative stress in a clever variety of ways, including pumping out more glutathione to neutralise free radicals, thereby reducing inflammation

High levels of caffeine can also stress the adrenal glands, indirectly affecting the body's ability to maintain balanced glutathione levels

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Although the inhibitory effect of erastin towards system xc is well-documented, nothing is known about its mechanism of action