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The short TM4 sequence C P C is characteristic of both P 1B-1 and P 1B-2 transporters, widely accepted to transport Cu I and Zn II /Cd II /Pb II , respectively, but each differs on the basis of residues in TM6 (Figure 56)

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Altered gut microbiota can signal through pattern recognition receptors on gut epithelial cells, activating the NF-B pathway and leading to changes in gut homeostasis [122]

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As we mentioned, it's remarkably stable in gastric acid