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reported that downregulated IIS increased tau phosphorylation, promoted GSK activation, and decreased insulin receptor substrate-1 (IRS1), phospho-Akt, drebrin, and postsynaptic density (PSD95) resulting in cognitive impairment in the HFD model [156]

Bastien DAUPHIN (2019-2022)

Gln metabolism directly or indirectly influences epigenetic processes, such as DNA methylation and histone modification, through mechanisms of substrate supply and cofactor regulation

Data points were taken every 30 min for 6 h and at 24 h and 24.5 h

Keywords Information Type Research Article Information Copyright The Author(s), 2026

doi: 10.1038/s41580-020-00324-8 33 KaganVEMaoGQuFAngeliJPDollSCroixCSet al