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[DOI] [PMC free article] [PubMed] [Google Scholar] Maerker G

Therefore, these results indicate that, although DNA repair is an important mechanism, other mechanisms may play a primary role in determining resistance to cisplatin, especially in NCI H23 cell line

the mutated nucleotide is underlined

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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig