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In triple-negative breast cancer (MDA-MB-231 and 4T1) cells, emodin targets nuclear receptor corepressor 2 (NCOR2) to upregulate seryl-tRNA synthetase (SerRS), suppressing VEGFA transcription and angiogenesis [440]

Recent studies have shown that lipophilic statins may have certain therapeutic effects on neurodegenerative diseases, potentially exerting their benefits through various mechanisms such as anti-inflammatory and antioxidant actions

LDHC, lactate dehydrogenase C

10.1021/acs.jpcb.5b12618 101 TopalianS

DSIP's precise receptor has not been cloned or definitively characterized as of published literature

One day prior to the neutralization assay, 15 10 3 Huh-7 cells per well in a 96-well plate were seeded in 100 L DMEM/10% FCS/0.1% PS/1% nonessential amino acids/1% HEPES buffer (Huh-7 medium)