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doi: 10.1089/ars.2011.4198

First, the allowable extent or concentration of denatured protein, peptide or antibody for a specific dosage must be identified analytically

When activated, AhR dissociates from the cytosolic complex formed with HSP90, translocates into the nucleus where it heterodimerizes with AhR Nuclear Translocator (ARNT) and eventually binds to specific DNA sequences (Xenobiotic Responsive Elements, XRE) in the promoter region of its target genes, thus initiating gene transcription

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