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Clinical experience strongly supports its use for the indications below but we're working with promising preclinical data, not robust human RCTs

With the metabolic reprogramming of NADPH, cancer cells increase the demand of NADPH for antioxidative effects and anabolic reactions

ROS, such as superoxide (O 2 - ), can be produced in mitochondrial complexes I and III in components of the tricarboxylic-acid cycle, including -ketoglutarate dehydrogenase (EC 1.2.4.2), and in the outter mitochondrial membrane, damaging cell components such as lipids, proteins and DNA [25, 47]

Possible side effects include injection-site soreness, redness, nausea, or headache

37 :90S-102S 116

doi: 10.1074/jbc.274.10.6366