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Only after the new drug has been subject to many years of testing on volunteer patients, and a comprehensive investigation into any side-effects and any other possible complications has taken place will the evidence be placed before the MHRA

22 , 23 , 56 Treatments such as antibiotics, proton pump inhibitor medications, antihyperglycemic medicines (eg, metformin), nitrous oxide anesthesia, a nonsteroidal anti-inflammatory drug, some anticonvulsants, and colchicine interfere with B 12 absorption and metabolism

Case presentations All patients in this study received treatment by their private physicians prior to entering the study

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