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Successful treatment of rheumatoid arthritis is associated with a reduction in serum sE-selectin and thrombomodulin level

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An alternative strategy is based on targeting tumor necrosis factor alpha (TNF-), a pro-inflammatory cytokine that has increased levels in AD

This compound may also explain why vitamin B12 has been shown to be extremely helpful for sleep disorders, as melatonin regulates the sleep-wake cycle