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Therapeutic Benefits of Adropin in Aged Mice After Transient Ischemic Stroke via Reduction of Blood-Brain Barrier Damage

TRAM (TRIF-related adapter molecule) acts as a bridge adapter between TRIF (TIR-domain-containing adapter-inducing interferon-) and TLR4

FDA (2014)

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Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

The SURMOUNT-1 trial reported -22.5% weight reduction at the 15 mg weekly dose across 72 weeks (PMID 35658024)