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Moreover, increased intracellular copper levels activate multiple signaling pathways, such as mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) and B-rapidly accelerated fibrosarcoma (BRAF),which stimulate cell proliferation, promote angiogenesis via vascular endothelial growth factor (VEGF) activation (Pan et al., 2002), and enhance tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) (Zhang et al., 2025)

First study Tehrani, H

Liang R, Ghaffari S

Satyanarayana T, Kunze G, editors

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[DOI] [PubMed] [Google Scholar] 67.Dengler E.C., Liu J., Kerwin A., Torres S., Olcott C.M., Bowman B.N., Armijo L., Gentry K., Wilkerson J., Wallace J