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This cooperative effect is most noticeable during cellular energy shifts, when ATP levels fall to 2mM, unfolding occurs in the regulatory domains ATP-binding pocket (D294-R301), this increases the overall conformational entropy of the protein and enhances the catalytic efficiency for scarce substrates ( Under pathological conditions, abnormal modifications of protein domains significantly disrupt their functional stability

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

Chapter seven - host responses to biofilm, in , edsSan FranciscoM.San FranciscoB., (Cambridge, MA: Academic Press), 193239

A classic example is p53, which contains IDRs at both its N- and C-termini

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