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Therefore, these data suggest that IL-27 may be involved in the pathogenesis of inflammatory lung diseases

Inhibition of glutamate uptake by S1P contrasts with S1P receptor modulator effects

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Interestingly, in this process syntaxin18 (STX18) revealed functions as a negative regulator, binding ATG14 and disrupting its interaction with ATG8 family proteins, which inhibits the formation of the PI3KC3-C1 complex and, consequently, lipophagy

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This cysteine is also evolutionarily conserved and specifically S -nitrosylated in both human and fly NADPH oxidases, suggesting that this mechanism may govern immune responses in both plants and animals (Yun et al., 2011)