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doi: 10.1038/s41586-019-1785-z 97 SongXSunXOhSFWuMZhangYZhengWet al

New evidence suggests that these metabolites are closely associated with ferroptosis in IBD and its pathological processes, indicating that metabolites from gut microbes play a role in controlling IBD onset through the mediation of ferroptosis [11, 12]

Bcl2l1 ) [133, 134]

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The P2X7 receptor plays a role in regulating the redox potential and can serve as an inducer of H 2 O 2 production, facilitated by the release of Ca2 + (179)

High levels of Zn, Cd, Cu, Fe, and/or Ni can significantly induce the expression of NA synthase genes (responsible for the synthesis of NA by trimerization of S-adenosylmethionine) (reviewed by Hassan and Aarts, 2011