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peroxide induces loss of mitochondrial membrane potential, increases free intracellular calcium, and causes direct oxidation to lipids and DNA strand breaks (Hoyt et al., 1997

It is evident from MD that the 1-3 arm of #105, #107 and #108 can bind to the GnT-IVa lectin domain in a manner in which 1-2GlcNAc or 1-4GlcNAc occupies the primary GlcNAc binding site

After a landmark 2003 study revealed it as a powerful activator of sirtuins, and subsequent studies showed its ability to extend lifespan (by 10% in roundworms and fruit flies, and 25% in mice), it quickly captured global attention and sparked an explosion of research into its potential for human health and longevity.*6,7,8