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After deduplication and standardization, the final UC-related targets were obtained

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Concurrently, lack of Nrf2 decreased protein aggregation and cardiac hypertrophy and improved cardiac contractility in the mice transgenic for the mutant human B-crystallin, suggesting that the sustained upregulation of Nrf2 and subsequent increase in GSH-mediated removal of hydrogen peroxide contributes to the reductive stress phenotype [51]

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