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[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Wang J., Kitagawa K., Kitado H., Kogishi K., Matsushita T., Hosokawa M., Higuchi K

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However, OA is not a simple cartilage degenerative disease but a complex condition involving multiple tissues and cells, including cartilage, synovium, subchondral bone, osteophyte formation, joint capsule, and local immune cell populations

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This is something that drinking water alone cannot always achieve

Non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin inhibit cyclooxygenase and eventually prostaglandin synthesis