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Development of interventions targeting amyloid beta plaques and tau protein tangles also have not been successful [8, 9], and the number of phase 3 trials focused on amyloid intervention has decreased since 2019 [10]

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196,197 Importantly, in both trials, the duration of NMB in the study protocol was intentionally short (48 h), with no difference in the incidence of ICU-acquired weakness with NMB

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