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Calle, A

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However, these standard treatments have important limitations and unmet clinical needs

Figure 2 3.1 Cancer-associated fibroblasts CAFs, the highly heterogeneous stromal cells in TME, play versatile roles in ECM remodeling, inducing angiogenesis, modulating tumor metabolism, excluding immune response, and promoting tumor progression and therapeutic resistance based on intricate signaling crosstalk with tumor cells ( As the bad neighbors of tumor cells, the proliferation and migration of CAFs are considered necessary for tumor progression

In fact, geraniin, at a dose of 20 mg/kg injected intraperitoneally, was recently shown to ameliorate cisplatin-induced nephrotoxicity in mice by inhibiting OS and inflammatory response ( Geraniin has also been reported to exhibit neuroprotection in an in vitro study

Researchers reviewing peptide materials often look for evidence that the material matches the expected identity and that analytical purity has been assessed