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However, the parenteral route of administration has several drawbacks, since it is invasive, painful, and poorly accepted by patients, especially when prolonged or repeated use is required [5]

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Less BAC water = higher concentration = fewer units per dose (more practical for large doses, but precision decreases)

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Consequently, Nb1053 has been radiolabeled with 18 F, resulting in a radioconjugate excreted via the hepatobiliary system, that prevents renal accumulation without compromising tumor uptake [99,100,101,102,103,104,105,106,107,108,109]

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