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10.1016/j.fct.2023.113846 Food Chem

Analyses of the effects of FFA (NEFA) on macrophages in cell culture demonstrated that they can activate inflammatory signaling through the toll-like receptors (TLR), specifically TLR4

The literature does not show a causal link between these specific peptides and recurrence, but the prudence is warranted

PMID: 3 CordaniMDandoIAmbrosiniGGonzlez-MenndezP

Potential side effects could range from mild to severe, including allergic reactions, injection site complications, and systemic effects

Subjective improvement in pain, function, and activity tolerance provides the primary effectiveness signal