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Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, Lopez EF, Ghasemi O et al (2013) Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice

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They found that the loss in pathogenesis was mainly caused by the loss of DsbA protein, which subsequently led to the loss of the type III secretion system, cell adhesion, and twitching motility due to low levels of pili expression

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Weinert BT, Moustafa T, Iesmantavicius V, Zechner R, Choudhary C

Importantly, any of the adverse events that were reported by patients were mild and no more prevalent or serious when compared to the group that received a placebo